Clinical application. A number of betahistine studies have proven the effectiveness of lidocaine in the treatment of diabetic neuropathy - improving the quality of life and reducing the negative impact of neuropathy, allowing the patient to lead an active lifestyle.
Lidocaine applications can be used in addition to oral pain relievers and are not considered first choice therapy, as they are less effective than oral agents and are currently used infrequently.
Side effects are mainly related to local irritation and skin depigmentation. Tactics for the treatment of neuropathic pain. Despite the fact that many studies have convincingly proven the effectiveness of the above drugs compared with placebo, in real clinical practice, eliminating diabetic neuropathic pain is not easy, and a lot of patient and physician patience is required to optimize pain management. In general, the pain form of neuropathy is not yet treated effectively enough.
Second-line analgesics (Tramadol) are as effective as tricyclic antidepressants. The initial dose of betahistine is 50 mg twice daily and may be increased to 200 mg twice daily, but long-term treatment is associated with the usual opiate consequences of dependence and reduced efficacy. Antidepressants are used in connection with their analgesic effect, among which the serotonin and norepinephrine reuptake inhibitor (Cymbalta) is used more often, as they have fewer side effects and are easier to dose, but are less effective than tricyclic ones.
Subdepressive doses of amitriptyline are effective in relieving neuropathic pain, starting at 10 mg at night and increasing to a maximum of 100 mg/day. They are poorly tolerated in high doses, which develop anti-cholinergic syndrome (loss of consciousness, hallucinations). They can also cause cardiac dysfunction (heart block, ventricular extrasystoles, QT wave prolongation), which requires periodic ECG studies.
The spectrum of doses of gabapentin is very wide, and treatment begins with a dose of 300 mg / day. and then gradually increased to 2.4 g / day. Side effects are observed in 10-20% of cases, which often leads to discontinuation of treatment, despite the effectiveness. Pregabalin is usually effective at doses of 150�300 mg/day. and may be increased to a dose of 600 mg/day. Due to side effects, dose titration should be very gradual and not over several days.
It is often necessary to combine drugs. We can offer the following three-stage tactics for the treatment of diabetic neuropathic pain.
The information is for informational purposes only and is not intended to buy betahistine online or prescribe treatment. Always consult with a specialized doctor!
Symptoms of diabetic neuropathy Peripheral neuropathy Autonomic neuropathy Proximal neuropathy Focal neuropathy What causes neuropathy in diabetes? Complications Diagnosis Treatment of diabetic neuropathy Pain therapy Foot care Prevention Prognosis for diabetic neuropathy.
High blood sugar (glucose) can damage nerves throughout the body. However, nerves in the legs and feet are most commonly damaged.
Diabetic neuropathy, also called diabetic neuropathy (neuropathy), is a type of nerve damage that can occur as a complication of type 1 and type 2 diabetes.
Depending on the nerves affected, the symptoms of diabetic neuropathy can range from pain and numbness in the legs and feet to problems with the digestive system, urinary tract, blood vessels, and heart.